SCHEMBL44658

SCHEMBL44658

Oc1ccc(C(c2ccc(O)cc2)C(Cl)(Cl)Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 9/20 1.00
ESR2 Q92731 7/20 1.00
TSHR P16473 4/20 0.61
TDP1 Q9NUW8 4/20 0.61
LMNA P02545 3/20 0.61
HIF1A Q16665 3/20 0.61
MAPK1 P28482 2/20 0.61
HPGD P15428 2/20 0.61
TP53 P04637 1/20 0.61
ALDH1A1 P00352 3/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
PDCD1 Q15116 1/20 0.46
CD274 Q9NZQ7 1/20 0.46
CYP3A4 P08684 3/20 0.42
ALOX15 P16050 3/20 0.42
MAPT P10636 2/20 0.42
NFKB1 P19838 2/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11317436 0.97 ESR1 (0.95) ESR1ESR2TSHRTDP1LMNA
SCHEMBL4381254 0.91 ESR1 (0.83) ESR1ESR2TSHRTDP1LMNA
SCHEMBL15263150 0.84 MAPK1 (0.81) ESR1ESR2TSHRTDP1LMNA
SCHEMBL11551568 0.80 ESR1 (0.64) ESR1ESR2TSHRTDP1LMNA
SCHEMBL8580685 0.79 ESR1 (0.65) ESR1ESR2TSHRTDP1LMNA
SCHEMBL28501352 0.79 ESR1 (0.65) ESR1ESR2TSHRTDP1LMNA
SCHEMBL7120983 0.77 ESR1 (0.62) ESR1ESR2TSHRTDP1LMNA
Chlorophenothane SCHEMBL7181 0.76 TSHR (1.00) ESR1ESR2TSHRTDP1LMNA
SCHEMBL3682920 0.76 ESR1 (1.00) ESR1ESR2TSHRTDP1LMNA
Chlorophenothane SCHEMBL2065589 0.76 TSHR (1.00) ESR1ESR2TSHRTDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 635 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12538063-B2 Method and system for authentication and compensation HARMAN INTERNATIONAL INDUSTRIES, INCORPORATED (US) 2026-01-27 US claimed
US-11591632-B2 Genetically-mutated bacterial strain for detecting estrogenic compound and method for detecting estrogenic compound using the same INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) 2023-02-28 US claimed
US-20220318139-A1 PROCESSOR SUPPORTING TRANSLATION LOOKASIDE BUFFER (TLB) MODIFICATION INSTRUCTION FOR UPDATING HARDWARE-MANAGED TLB AND RELATED METHODS MICROSOFT TECHNOLOGY LICENSING, LLC 2022-10-06 US claimed
WO-2022212022-A1 PROCESSOR SUPPORTING TRANSLATION LOOKASIDE BUFFER (TLB) MODIFICATION INSTRUCTION FOR UPDATING HARDWARE-MANAGED TLB AND RELATED METHODS MICROSOFT TECHNOLOGY LICENSING, LLC (US) 2022-10-06 WO claimed
US-20090163692-A1 AROMATIC POLYETHERS GENERAL ELECTRIC COMPANY (US) 2009-06-25 US claimed
EP-1763560-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2007-03-21 EP claimed
US-7109274-B2 Polyarylate compositions GENERAL ELECTRIC COMPANY (US) 2006-09-19 US claimed
WO-2006012161-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2006-02-02 WO claimed
US-20060004152-A1 Polyarylate compositions GENERAL ELECTRIC COMPANY 2006-01-05 US claimed
EP-0333002-B1 Heat-resistant resin composition IDEMITSU PETROCHEMICAL CO (JP) 1994-04-27 EP claimed
EP-0023914-B1 DEHYDROHALOGENATION OF A DIPHENYL TRICHLOROETHANE GENERAL ELECTRIC COMPANY (US) 1983-07-13 EP claimed
EP-0023914-A4 DEHYDROHALOGENATION OF A DIPHENYL TRICHLOROETHANE. GEN ELECTRIC (US) 1981-06-26 EP claimed
US-4269952-A Preparation of glycidyl polyarylethers RHONE-POULENC INDUSTRIES (FR) 1981-05-26 US claimed
EP-0023914-A1 DEHYDROHALOGENATION OF A DIPHENYL TRICHLOROETHANE. GEN ELECTRIC (US) 1981-02-18 EP claimed
US-4228308-A IN METHYLAMINE AND A SALT GENERAL ELECTRIC COMPANY (US) 1980-10-14 US claimed
WO-1980001688-A1 DEHYDROHALOGENATION OF A DIPHENYL TRICHLOROETHANE GEN ELECTRIC (US) 1980-08-21 WO claimed
US-4192957-A DEHYDROCHLORINATION OF 1,1,1-TRICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHANE TO 1,1-DICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHYLENE WITH LIQUID AMMONIA AND ALKYL AMINE HYDROHALIDE PROMOTER GENERAL ELECTRIC COMPANY (US) 1980-03-11 US claimed
US-4192956-A DEHYDROCHLORINATION OF 1,1,1-TRICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHANE TO 1,1-DICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHYLENE WITH LIQUID AMMONIA AND INORGANIC HALIDE PROMOTER GENERAL ELECTRIC COMPANY (US) 1980-03-11 US claimed
US-4180685-A WITH METHYLAMINE GENERAL ELECTRIC COMPANY (US) 1979-12-25 US claimed
US-4097538-A TREATING WITH LIQUID AMMONIA GENERAL ELECTRIC COMPANY (US) 1978-06-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12538063-B2 Method and system for authentication and compensation PNN, NTRK3, PTH1R ESR1 261/4885ESR2 77/4885TSHR 83/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.