Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586570 | 0.86 | NOX1 (0.36) | NOX1HCAR3 | |
| SCHEMBL8584147 | 0.85 | HPGD (0.36) | NOX1HCAR3MAPK1 | |
| SCHEMBL8582685 | 0.83 | NOX1 (0.40) | NOX1 | |
| SCHEMBL8585922 | 0.81 | NOX1 (0.38) | NOX1 | |
| SCHEMBL7066155 | 0.79 | HCAR3 (0.36) | HCAR3NAMPT | |
| SCHEMBL8580850 | 0.78 | HTR2A (0.39) | NOX1MAPK1 | |
| SCHEMBL8585872 | 0.77 | NOX1 (0.44) | NOX1 | |
| SCHEMBL16974872 | 0.76 | KMT2A (0.39) | NOX1 | |
| SCHEMBL8584509 | 0.75 | NOX1 (0.40) | NOX1 | |
| SCHEMBL7950883 | 0.74 | L3MBTL1 (0.38) | HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906297-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049692-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-12-31 | — | — | WO | disclosed |