Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17320482 | 0.86 | KMT2A (0.36) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL11988730 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL22855676 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL14001998 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL12014001 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL962818 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL3414738 | 0.83 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL7814108 | 0.83 | POLB (0.36) | POLB | |
| SCHEMBL21567775 | 0.82 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA | |
| SCHEMBL21910752 | 0.82 | KMT2A (0.34) | KMT2AMEN1L3MBTL1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066488-A2 | BRIDGED SPIRO[2.4]HEPTANE ESTER DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-24 | — | — | WO | disclosed |