Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.75 |
| ▸ | EDNRA | P25101 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314927 | 0.92 | EDNRB (0.79) | EDNRBEDNRAALDH1A1MAPK1HPGD | |
| SCHEMBL6315635 | 0.86 | EDNRB (1.00) | EDNRBEDNRAALDH1A1 | |
| SCHEMBL8798255 | 0.83 | EDNRB (0.79) | EDNRBEDNRAALDH1A1MAPK1HPGD | |
| SCHEMBL6314851 | 0.77 | EDNRB (0.75) | EDNRBEDNRAMAPTTSHRMEN1 | |
| SCHEMBL8578004 | 0.77 | EDNRB (0.86) | EDNRBEDNRA | |
| SCHEMBL8577096 | 0.76 | EDNRB (0.85) | EDNRBEDNRAALDH1A1MAPK1HPGD | |
| SCHEMBL795880 | 0.76 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8797682 | 0.75 | EDNRB (0.78) | EDNRBEDNRAMAPT | |
| SCHEMBL8576085 | 0.75 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8799108 | 0.75 | EDNRB (0.77) | EDNRBEDNRAALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |