Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578880 | 0.84 | MMP2 (0.56) | MMP2MMP9CA1CA2 | |
| SCHEMBL6578877 | 0.84 | MMP2 (0.56) | MMP2MMP9CA1CA2 | |
| SCHEMBL30998137 | 0.81 | FDPS (0.44) | FDPSEPHX2NPC1RAB9APKM | |
| SCHEMBL14052936 | 0.80 | FDPS (0.51) | FDPSEPHX2NPC1RAB9APKM | |
| SCHEMBL14053150 | 0.80 | FDPS (0.51) | FDPSEPHX2NPC1RAB9APKM | |
| SCHEMBL1133842 | 0.79 | LMNA (0.51) | HDAC4MEF2DEPHX2CYP2C9CYP2C19 | |
| SCHEMBL1133843 | 0.79 | CYP3A4 (0.56) | PKMCYP3A4FLT4CYP1A2CYP2C9 | |
| SCHEMBL22635849 | 0.79 | CYP3A4 (0.56) | PKMCYP3A4FLT4CYP1A2CYP2C9 | |
| SCHEMBL210916 | 0.79 | LMNA (0.51) | HDAC4MEF2DEPHX2CYP2C9CYP2C19 | |
| SCHEMBL2121460 | 0.79 | LMNA (0.51) | HDAC4MEF2DEPHX2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840835-A | MAJOR HISTOCOMPATIBILITY COMPLEX; USED IN THE TREATMENT AND PREVENTION OF AUTOIMMUNE DISEASES | MERCK & CO., INC. (US) | 1998-11-24 | — | — | US | disclosed |