Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976966 | 0.80 | LRRK2 (0.38) | MAPK14MAP4K4PRKACACLK2GSK3B | |
| SCHEMBL856913 | 0.70 | CDK2 (0.49) | MAP4K4PRKACAGSK3BLRRK2CLK4 | |
| SCHEMBL28388751 | 0.69 | TUBB4A (0.57) | IDO1MAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL671445 | 0.66 | CYP2A6 (0.54) | NR4A2MAPK14ABL1KDRDAPK3 | |
| SCHEMBL6772507 | 0.65 | FBP1 (0.48) | MAPK14MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL31517791 | 0.64 | NR4A2 (0.56) | NR4A2MAPK14ABL1KDRDAPK3 | |
| SCHEMBL857088 | 0.63 | LRRK2 (0.55) | MAPK14RETDYRK1ALRRK2DYRK1B | |
| SCHEMBL14845847 | 0.63 | LRRK2 (0.39) | NTRK1DYRK1ALRRK2DYRK1BALDH1A1 | |
| SCHEMBL858192 | 0.62 | LRRK2 (0.43) | ROCK1DYRK1ALRRK2DYRK1BRAB9A | |
| SCHEMBL857285 | 0.60 | LRRK2 (0.52) | LRRK2MAPTALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |