Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 4/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581618 | 1.00 | PNMT (0.47) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8105515 | 0.85 | PNMT (0.45) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL10599864 | 0.79 | PNMT (0.51) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8926136 | 0.76 | TACR1 (0.47) | PNMTSLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL4907481 | 0.75 | PNMT (0.65) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8369405 | 0.73 | PNMT (0.61) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8369404 | 0.73 | PNMT (0.61) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL15213093 | 0.71 | PNMT (0.50) | PNMTSLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL6005075 | 0.71 | KMO (0.48) | PNMTSLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL6005266 | 0.71 | KMO (0.48) | PNMTSLC6A2SLC6A4SLC6A3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025617-A1 | SUBSTITUTED ARYL PIPERAZINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |