Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 2/20 | 0.39 |
| ▸ | MC5R | P33032 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL8584754 | 0.97 | GHSR (0.43) | GHSRMEN1KMT2AKDM4ELMNA | |
| Valine SCHEMBL8434539 | 0.97 | GHSR (0.43) | GHSRMEN1KMT2AKDM4ELMNA | |
| D-Tryptophan SCHEMBL8585295 | 0.86 | KDM4E (0.48) | GHSRMEN1KMT2AKDM4ELMNA | |
| D-Tryptophan SCHEMBL8434542 | 0.86 | KDM4E (0.49) | GHSRMEN1KMT2AKDM4ELMNA | |
| D-Tryptophan SCHEMBL8584759 | 0.86 | KDM4E (0.49) | GHSRMEN1KMT2AKDM4ELMNA | |
| Methionine SCHEMBL6244204 | 0.82 | MEN1 (0.46) | GHSRMEN1KMT2AKDM4ELMNA | |
| Threonine SCHEMBL9220826 | 0.81 | KDM4E (0.55) | GHSRMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL7763177 | 0.81 | KDM4E (0.60) | GHSRMEN1KMT2AKDM4ELMNA | |
| Phenylalanine SCHEMBL7341867 | 0.80 | MEN1 (0.50) | GHSRMEN1KMT2AKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL9220819 | 0.80 | KDM4E (0.65) | GHSRMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833646-A4 | MULTI-TYROSINATED SOMATOSTATIN ANALOGS | UNIV LOUISIANA STATE MED (US) | 1998-05-27 | — | — | EP | disclosed |
| EP-0833646-A1 | MULTI-TYROSINATED SOMATOSTATIN ANALOGS | The Administrators of The Tulane Educational Fund (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039161-A1 | MULTI-TYROSINATED SOMATOSTATIN ANALOGS | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 1996-12-12 | — | — | WO | disclosed |