Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20394478 | 0.81 | CYP3A4 (0.46) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL2592326 | 0.80 | L3MBTL1 (0.42) | IDO1TSHRLMNAMAPTKDM4E | |
| SCHEMBL22556880 | 0.78 | LMNA (0.47) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL22719451 | 0.76 | MYC (0.54) | CYP3A4TDP1CYP1A2TSHRCYP2A6 | |
| SCHEMBL6306259 | 0.75 | CYP3A4 (0.43) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL15881144 | 0.75 | CYP3A4 (0.53) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL10761274 | 0.74 | CYP3A4 (0.50) | CYP3A4TDP1CYP1A2TSHRMKNK1 | |
| SCHEMBL3273101 | 0.74 | NCOA3 (0.45) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL29523312 | 0.73 | IDO1 (1.00) | IDO1CYP3A4TDP1CYP1A2TSHR | |
| SCHEMBL57158 | 0.73 | IDO1 (1.00) | IDO1CYP3A4TDP1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |