Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570392 | 0.80 | KDM4E (0.45) | LMNAMAPTCYP3A4CYP1A2IDO1 | |
| SCHEMBL8585682 | 0.78 | IDO1 (0.58) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL20394478 | 0.78 | CYP3A4 (0.46) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL15881144 | 0.75 | CYP3A4 (0.53) | MAPTCYP3A4CYP2A6TSHRCYP1A2 | |
| SCHEMBL21805951 | 0.74 | IDO1 (0.53) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL10761274 | 0.74 | CYP3A4 (0.50) | MAPTCYP3A4CYP2A6TSHRCYP1A2 | |
| SCHEMBL3273101 | 0.74 | NCOA3 (0.45) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL637804 | 0.73 | IDO1 (0.61) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL22719451 | 0.73 | MYC (0.54) | LMNAMAPTCYP3A4CYP2A6TSHR | |
| SCHEMBL29696523 | 0.71 | NOS3 (0.46) | LMNAMAPTCYP3A4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |