Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 5/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151902 | 0.91 | CTSB (0.46) | CTSBABCB1ALDH1A1SLC15A1LTA4H | |
| SCHEMBL8583695 | 0.89 | SLC15A1 (0.45) | CTSBABCB1ALDH1A1SLC15A1LTA4H | |
| SCHEMBL8586811 | 0.89 | CTSB (0.47) | CTSBABCB1SLC15A1LTA4HCTSL | |
| SCHEMBL8584621 | 0.88 | CTSB (0.41) | CTSBABCB1SLC15A1SLC1A3SLC1A2 | |
| SCHEMBL8587702 | 0.87 | CTSB (0.42) | CTSBABCB1ALDH1A1SLC15A1LTA4H | |
| SCHEMBL8583463 | 0.87 | EPHX1 (0.40) | CTSBABCB1ALDH1A1SLC15A1LTA4H | |
| SCHEMBL8586822 | 0.87 | CTSB (0.43) | CTSBABCB1SLC15A1LTA4HLAP3 | |
| SCHEMBL8586501 | 0.85 | CTSB (0.39) | CTSBABCB1ALDH1A1SLC15A1LTA4H | |
| SCHEMBL8584909 | 0.85 | CTSB (0.44) | CTSBCTSLCTSSCTSK | |
| SCHEMBL8583834 | 0.85 | SLC15A1 (0.40) | CTSBABCB1SLC15A1LTA4HLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | claimed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | claimed |
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | disclosed |