Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491171 | 0.85 | MMP8 (0.51) | MMP12MMP13MMP8ALDH1A1TBXA2R | |
| SCHEMBL8587219 | 0.82 | ALDH1A1 (0.47) | MMP12MMP13MMP8ALDH1A1TBXA2R | |
| SCHEMBL5859870 | 0.74 | ALDH1A1 (0.47) | MMP12MMP13MMP8ALDH1A1TBXA2R | |
| SCHEMBL1471504 | 0.74 | NR1H4 (0.51) | MMP12MMP13MMP8ALDH1A1TBXA2R | |
| SCHEMBL7105105 | 0.74 | MMP8 (0.43) | MMP12MMP13MMP8ALDH1A1TBXA2R | |
| SCHEMBL3207695 | 0.72 | MMP8 (0.60) | MMP12MMP13MMP8ALDH1A1L3MBTL1 | |
| SCHEMBL5476518 | 0.69 | ALDH1A1 (0.62) | MMP13MMP8ALDH1A1TBXA2RMAPT | |
| SCHEMBL1471098 | 0.69 | LTB4R (0.50) | TBXA2RTBXAS1FFAR1 | |
| SCHEMBL5725952 | 0.68 | CYP4F2 (0.51) | — | |
| SCHEMBL9002519 | 0.66 | MMP8 (0.59) | MMP12MMP13MMP8ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946501-A1 | PREVENTION OF LOSS AND RESTORATION OF BONE MASS BY CERTAIN PROSTAGLANDIN AGONISTS | PFIZER INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028264-A1 | PREVENTION OF LOSS AND RESTORATION OF BONE MASS BY CERTAIN PROSTAGLANDIN AGONISTS | PFIZER INC. (US) | 1998-07-02 | — | — | WO | disclosed |