Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RPA1 | P27694 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10759674 | 0.82 | ALDH1A1 (0.48) | COMTKDM4ELMNAPOLBRECQL | |
| SCHEMBL11579855 | 0.81 | KDM4E (0.54) | COMTKDM4ELMNAPOLBRECQL | |
| SCHEMBL11559547 | 0.80 | ALDH1A1 (0.71) | COMTKDM4ELMNAPOLBRECQL | |
| SCHEMBL10462449 | 0.80 | HPGD (0.45) | COMTALDH1A1HPGDMAOAMAOB | |
| SCHEMBL3410900 | 0.80 | GABRA2 (0.54) | KDM4ELMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL10759523 | 0.78 | BCL2L1 (0.50) | KDM4ELMNAPOLBRECQLALDH1A1 | |
| SCHEMBL10762153 | 0.78 | LMNA (0.49) | COMTKDM4ELMNAPOLBRECQL | |
| SCHEMBL26986724 | 0.77 | ALDH1A1 (0.49) | COMTKDM4EALDH1A1RPA1MAPT | |
| SCHEMBL10756831 | 0.77 | LMNA (0.48) | KDM4ELMNAPOLBRECQLALDH1A1 | |
| SCHEMBL10761367 | 0.77 | KMT2A (0.53) | KDM4ELMNAPOLBRECQLRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149735-A1 | 1,4-Dihydropyridine Derivatives and Their Uses | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2012-06-14 | — | — | US | disclosed |
| EP-2432763-A1 | 1,4 DIHYDROPYRIDINE DERIVATIVES AND THEIR USES | Université de Lille 2 Droit et Santé (FR) | 2012-03-28 | — | — | EP | disclosed |
| EP-2261211-A1 | 1,4-dihydropyridine derivatives and their uses | Université de Lille 2 Droit et Santé (FR) | 2010-12-15 | — | — | EP | disclosed |
| WO-2010133973-A1 | 1,4 DIHYDROPYRIDINE DERIVATIVES AND THEIR USES | UNIVERSITE LILLE 2 DROIT ET SANTE (FR) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149735-A1 | 1,4-Dihydropyridine Derivatives and Their Uses | CNR2, CNR1, TRPV1 | COMT 1215/4885KDM4E 1773/4885LMNA 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.