Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 7/20 | 0.40 |
| ▸ | NPY1R | P25929 | 5/20 | 0.40 |
| ▸ | NPY2R | P49146 | 4/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.40 |
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | VIPR2 | P41587 | 5/20 | 0.37 |
| ▸ | VIPR1 | P32241 | 3/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL27448866 | 0.99 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RAPLNR | |
| Tyrosine SCHEMBL27677075 | 0.96 | NPY4R (0.43) | NPY4RNPY1RNPY2RNPY5RVIPR2 | |
| Tyrosine SCHEMBL27506997 | 0.95 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RAPLNR | |
| Tyrosine SCHEMBL27431939 | 0.95 | NPY4R (0.42) | NPY4RNPY1RNPY2RNPY5RVIPR2 | |
| Tryptophan SCHEMBL27389650 | 0.93 | TUBB4A (0.44) | NPY2RTUBB4ATUBBTUBA3CTUBA1B | |
| Cystine SCHEMBL27543315 | 0.92 | APLNR (0.38) | APLNRVIPR2VIPR1TUBB4ATUBB | |
| Tyrosine SCHEMBL27636887 | 0.92 | GLP1R (0.40) | VIPR2VIPR1GLP1R | |
| Tyrosine SCHEMBL27801169 | 0.91 | CALCR (0.35) | GLP1R | |
| Tyrosine SCHEMBL27657510 | 0.91 | TUBB4A (0.39) | APLNRVIPR2TUBB4ATUBBTUBA3C | |
| Arginine SCHEMBL8587378 | 0.90 | APLNR (0.37) | NPY4RNPY1RNPY2RNPY5RAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10245399-A | — | — | None | — | — | JP | disclosed |
| CN-1860237-A | Method for purifying succinic acid from fermentation broth | AJINOMOTO KK (JP) | 2006-11-08 | — | — | CN | disclosed |
| JP-H10245399-A | NEW LECTIN, ITS PRODUCTION AND USE | TEIKA CORP | 1998-09-14 | — | — | JP | disclosed |
| CN-1110096-A | Method for processing vaccinium bracteatum seed powder | HAN SHAONAN (CN) | 1995-10-18 | — | — | CN | disclosed |