SCHEMBL8587477

SCHEMBL8587477

CCCc1c(O)ccc2c1OC(C(=O)OCC)CC2

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 18/20 0.50
LTB4R2 Q9NPC1 7/20 0.50
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
CYSLTR2 Q9NS75 1/20 0.43
CYSLTR1 Q9Y271 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957180 0.89 LTB4R (0.51) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL10639016 0.85 LTB4R (0.60) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL10635508 0.82 CYP4F2 (0.50) LTB4RLTB4R2CYP4F2CYP4A11CYSLTR2
SCHEMBL10408808 0.82 LTB4R (0.44) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL8586654 0.82 LTB4R (0.59) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL8670848 0.82 LTB4R (0.61) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL10632270 0.80 LTB4R (0.52) LTB4RLTB4R2CYP4F2CYP4A11CYSLTR2
SCHEMBL8583246 0.80 CYP4F2 (0.50) LTB4RLTB4R2CYP4F2CYP4A11
SCHEMBL10636370 0.79 LTB4R (0.57) LTB4RLTB4R2CYSLTR2CYSLTR1
SCHEMBL8314473 0.78 CYP4F2 (0.56) LTB4RLTB4R2CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0735870-A4 USE OF PLA 2? INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE LILLY CO ELI (US) 1998-08-19 EP disclosed
WO-1996036347-A1 USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1996-11-21 WO disclosed
EP-0743064-A1 Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease ELI LILLY AND COMPANY (US) 1996-11-20 EP disclosed
EP-0735870-A1 USE OF PLA 2? INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1996-10-09 EP disclosed
US-5563164-A TREATING ARTHRITIS, PSORIASIS, ASTHMA, INFLAMMATORY BOWEL DISEASE, OR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1996-10-08 US disclosed
US-5478857-A Administering inhibitor of phospholipase A2 ELI LILLY AND COMPANY (US) 1995-12-26 US disclosed
US-5462954-A Antiinflammatory, antiallergens; treating asthma ELI LILLY AND COMPANY (US) 1995-10-31 US disclosed
WO-1995017183-A1 USE OF PLA2 INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed
EP-0544488-A2 Substituted phenyl phenol leukotriene antagonists ELI LILLY AND COMPANY (US) 1993-06-02 EP disclosed
US-4788214-A ANTIALLERGENS HOFFMAN-LA ROCHE INC. (US) 1988-11-29 US disclosed
US-4785017-A ANTIALLERGENS HOFFMANN-LA ROCHE INC. (US) 1988-11-15 US disclosed
EP-0129906-B1 PHENOXYALKOXY-3,4-DIHYDRO-2H-1-BENZOPYRAN DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1988-06-08 EP disclosed