Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587477 | 0.89 | LTB4R (0.50) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL10639016 | 0.86 | LTB4R (0.60) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL9821777 | 0.81 | LTB4R (0.62) | LTB4RLTB4R2 | |
| SCHEMBL8957123 | 0.81 | LTB4R (0.61) | LTB4RLTB4R2 | |
| SCHEMBL5723187 | 0.81 | NFKB1 (0.43) | LTB4RLTB4R2 | |
| SCHEMBL8957027 | 0.80 | LTB4R (0.60) | LTB4RLTB4R2 | |
| SCHEMBL10343032 | 0.80 | LTB4R (0.54) | LTB4RLTB4R2 | |
| SCHEMBL10838006 | 0.79 | LTB4R (0.62) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL11003592 | 0.78 | LTB4R (0.47) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL5183040 | 0.78 | LTB4R (0.83) | LTB4RLTB4R2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532383-A | Leukotriene B4 antagonists | G. D. SEARLE & CO. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0593478-B1 | LEUKOTRIENE B 4 ANTAGONISTS | SEARLE & CO (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5439937-A | Leukotriene B4 antagonists | G. D. SEARLE & CO. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5310951-A | Benzopyran-2-propanoic acid derivatives; antiinflammatory agents | G.D. SEARLE & CO. (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0593478-A1 | LEUKOTRIENE B 4? ANTAGONISTS. | SEARLE & CO (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5124350-A | Antiinflammatory agent | G. D. SEARLE & CO. (US) | 1992-06-23 | — | — | US | disclosed |
| WO-1992000011-A2 | LEUKOTRIENE B4 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-01-09 | — | — | WO | disclosed |
| EP-0292977-B1 | ALKOXY-SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATE DERIVATIVES | G.D. Searle & Co. (US) | 1991-09-04 | — | — | EP | disclosed |
| EP-0150447-B1 | SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATES | G.D. Searle & Co. (US) | 1990-01-24 | — | — | EP | disclosed |
| US-4889871-A | ANTIINFLAMMATORY AGENTS; SELECTIVE LEUKOTRIENE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0292977-A1 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives | G.D. Searle & Co. (US) | 1988-11-30 | — | — | EP | disclosed |
| US-4778903-A | Substituted dihydrobenzopyrans | G. D. SEARLE & CO. (US) | 1988-10-18 | — | — | US | disclosed |
| US-4665203-A | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors | G. D. SEARLE & CO. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4565882-A | Substituted dihydrobenzopyran-2-carboxylates | G. D. SEARLE & CO. (US) | 1986-01-21 | — | — | US | disclosed |
| EP-0150447-A2 | Substituted dihydrobenzopyran-2-carboxylates | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |
| EP-0139809-A1 | Substituted dihydrobenzopyrans | G.D. Searle & Co. (US) | 1985-05-08 | — | — | EP | disclosed |