Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588618 | 0.96 | HRH3 (0.41) | KDRKITFLT3ROCK2ROCK1 | |
| SCHEMBL8590672 | 0.95 | KDR (0.45) | KDRKITFLT3ROCK2ROCK1 | |
| SCHEMBL8589814 | 0.88 | HRH3 (0.42) | KDRKITFLT3ROCK2ROCK1 | |
| SCHEMBL8589856 | 0.86 | HTR1D (0.47) | KDRKITFLT3MCHR1HRH3 | |
| SCHEMBL8588968 | 0.85 | MCHR1 (0.41) | KDRKITFLT3ROCK2ROCK1 | |
| SCHEMBL8587765 | 0.83 | HTR1D (0.44) | MCHR1KMT2AKDM4EALDH1A1HTR2C | |
| SCHEMBL8587717 | 0.82 | RAB9A (0.53) | HRH3KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8591092 | 0.81 | KDR (0.39) | KDRKITFLT3ROCK2ROCK1 | |
| SCHEMBL8590131 | 0.79 | MCHR1 (0.53) | KDRKITFLT3MCHR1HRH3 | |
| SCHEMBL8617369 | 0.77 | HTR1D (0.59) | ROCK2ROCK1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |