Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588618 | 0.86 | HRH3 (0.41) | HTR1DHTR1BCYP3A4CYP2D6IMPDH2 | |
| SCHEMBL8589654 | 0.85 | HTR1D (0.44) | HTR1DHTR1BHTR1AALDH1A1MAPT | |
| SCHEMBL8587699 | 0.83 | KDR (0.43) | ALDH1A1IMPDH2HTR2CHTR2BKMT2A | |
| SCHEMBL8590672 | 0.78 | KDR (0.45) | ALDH1A1IMPDH2KMT2AKDM4EMCHR1 | |
| SCHEMBL8613884 | 0.77 | HTR1A (0.59) | HTR1DHTR1BHTR1AALDH1A1MAPT | |
| SCHEMBL8615090 | 0.76 | HTR6 (0.49) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL8587499 | 0.74 | MEN1 (0.54) | MAPTCYP1A2MEN1KMT2ATRPV1 | |
| SCHEMBL8657486 | 0.72 | KDM4C (0.38) | HTR1DHTR1BHTR1AALDH1A1HTR2C | |
| SCHEMBL8615837 | 0.71 | POLB (0.39) | HTR1DHTR1BHTR1AALDH1A1MAPT | |
| SCHEMBL8589814 | 0.70 | HRH3 (0.42) | HTR1DHTR1BALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | claimed |
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |