Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441283 | 0.86 | HTT (0.72) | HTTTDP1CYP19A1PTGS2LMNA | |
| SCHEMBL527567 | 0.86 | HTT (0.72) | HTTTDP1CYP19A1PTGS2LMNA | |
| Methyl Alcohol SCHEMBL27770206 | 0.82 | HTT (0.68) | HTTTDP1CYP19A1PTGS2LMNA | |
| SCHEMBL7296254 | 0.79 | GPR35 (0.50) | HTTTDP1LMNASMN1; SMN2PKM | |
| SCHEMBL96840 | 0.79 | ALDH1A1 (0.54) | HTTTDP1LMNASMN1; SMN2PKM | |
| SCHEMBL9595423 | 0.78 | TDP1 (0.60) | HTTTDP1CYP19A1PTGS2LMNA | |
| SCHEMBL1191133 | 0.78 | HSD17B10 (0.56) | LMNASMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL7238168 | 0.78 | HTT (0.62) | HTTTDP1CYP19A1PTGS2LMNA | |
| SCHEMBL2147229 | 0.78 | ALDH1A1 (0.53) | HTTTDP1SMN1; SMN2PKMKMT2A | |
| SCHEMBL2372164 | 0.77 | HTT (0.60) | HTTTDP1CYP19A1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |