SCHEMBL8588261

SCHEMBL8588261

Cc1cc(C)c(B(c2c(C)cc(C)cc2CCl)c2cccc3ccccc23)c(CCl)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.40
CYP2A6 P11509 4/20 0.40
ALDH1A1 P00352 2/20 0.36
NR3C1 P04150 1/20 0.34
PGR P06401 1/20 0.34
NR3C2 P08235 1/20 0.34
CYP2C19 P33261 3/20 0.34
CYP2D6 P10635 1/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 1/20 0.34
IDH1 O75874 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NPC1 O15118 1/20 0.32
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
EPHX2 P34913 1/20 0.32
TACR1 P25103 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7456742 0.91 CYP1A2 (0.33) CYP1A2CYP2A6NPC1MAPTRAB9A
SCHEMBL8054073 0.88 CYP1A2 (0.37) CYP1A2CYP2A6L3MBTL1NPC1MAPT
SCHEMBL7914780 0.85 CYP2A6 (0.50) CYP1A2CYP2A6ALDH1A1NR3C1PGR
SCHEMBL8588453 0.83 ALDH1A1 (0.41) CYP1A2CYP2A6ALDH1A1CYP3A4HPGD
SCHEMBL7459767 0.79 KMT2A (0.33) ALDH1A1CYP3A4HPGDHSD17B10L3MBTL1
SCHEMBL8590039 0.78 LMNA (0.35) ALDH1A1L3MBTL1RAB9ASMN1; SMN2
SCHEMBL8436945 0.77 KMT2A (0.40) RAB9ATSHR
SCHEMBL8588371 0.76 FFAR4 (0.37) CYP1A2CYP2A6NPC1MAPTRAB9A
SCHEMBL7467880 0.75 CYP1A2 (0.42) CYP1A2CYP2A6ALDH1A1HPGDHSD17B10
SCHEMBL13994403 0.75 CYP1A2 (0.46) CYP1A2CYP2A6ALDH1A1NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5807905-A POLYMERIZATION OF UNSATURATED COMPOUNDS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-09-15 US disclosed