Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.49 |
| ▸ | MEN1 | O00255 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15047097 | 1.00 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8859290 | 1.00 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9068354 | 0.88 | LMNA (0.53) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9067641 | 0.88 | LMNA (0.53) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9067785 | 0.86 | MAPT (0.54) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9067783 | 0.86 | MAPT (0.54) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8588814 | 0.86 | MEN1 (0.66) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8859283 | 0.86 | MEN1 (0.66) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8859333 | 0.83 | ALDH1A1 (0.49) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9068162 | 0.83 | ALDH1A1 (0.54) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810864-A4 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0810864-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | Merck & Co., Inc. (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5670504-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO. INC. (US) | 1997-09-23 | — | — | US | disclosed |
| WO-1996025936-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |