Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | PRKCI | P41743 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29955671 | 0.81 | KMT2A (0.43) | LRRK2TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL3723388 | 0.81 | MET (0.43) | LRRK2TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL4582883 | 0.81 | MET (0.40) | LRRK2TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL13903471 | 0.75 | ALDH1A1 (0.54) | TDP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2316717 | 0.75 | CHEK1 (0.53) | TDP1KMT2AKDM4ECHEK1AKT1 | |
| SCHEMBL29953624 | 0.75 | KMT2A (0.46) | LRRK2TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL1467726 | 0.75 | ALDH1A1 (0.33) | TDP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16785960 | 0.75 | LRRK2 (0.62) | LRRK2CDK2CDK9CDK5AURKB | |
| SCHEMBL30498278 | 0.74 | ALDH1A1 (0.39) | TDP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27199467 | 0.74 | ALDH1A1 (0.39) | TDP1MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855473-B1 | PROCESS FOR PREPARING INTERMEDIATES COMPOUND | GENENTECH INC (US) | 2018-10-03 | — | — | EP | claimed |
| US-9221813-B2 | Intermediates and processes for preparing compounds | GENENTECH, INC. (US) | 2015-12-29 | — | — | US | claimed |
| US-20150105557-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING COMPOUNDS | GENENTECH, INC. | 2015-04-16 | — | — | US | claimed |
| EP-2855473-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING COMPOUNDS | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | claimed |
| WO-2013163109-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING COMPOUNDS | GENENTECH, INC. (US) | 2013-10-31 | — | — | WO | claimed |
| EP-2855473-B1 | PROCESS FOR PREPARING INTERMEDIATES COMPOUND | GENENTECH INC (US) | 2018-10-03 | — | — | EP | disclosed |
| US-20180111929-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180111929-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2016-06-23 | — | — | US | disclosed |
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2016-06-23 | — | — | US | disclosed |
| US-9221813-B2 | Intermediates and processes for preparing compounds | GENENTECH, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221813-B2 | Intermediates and processes for preparing compounds | GENENTECH, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
| US-20090264399-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-10-22 | — | — | US | disclosed |
| EP-1910358-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | LRRK2 725/4885TDP1 1409/4885MEN1 4089/4885 |
| US-20150105557-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING COMPOUNDS | CHEK1, CHEK2, PLK1 | LRRK2 869/4885TDP1 309/4885MEN1 543/4885 |
| US-20180111929-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | LRRK2 491/4885TDP1 631/4885MEN1 1452/4885 |
| US-20090264399-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | JAK3, JAK2, JAK1 | LRRK2 444/4885TDP1 3111/4885MEN1 923/4885 |
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | LRRK2 491/4885TDP1 631/4885MEN1 1452/4885 |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | LRRK2 491/4885TDP1 631/4885MEN1 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.