Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590301 | 0.95 | SLC6A3 (0.37) | SLC6A3OPRK1OPRM1P2RX3ALDH1A1 | |
| SCHEMBL8290867 | 0.90 | MEN1 (0.39) | SLC6A3P2RX3ALDH1A1KDM4EMEN1 | |
| SCHEMBL8300283 | 0.80 | MEN1 (0.40) | SLC6A3P2RX3MEN1KMT2ASIGMAR1 | |
| SCHEMBL8592687 | 0.80 | SLC6A3 (0.45) | SLC6A3OPRK1OPRM1P2RX3MEN1 | |
| SCHEMBL8352398 | 0.80 | SLC6A3 (0.45) | SLC6A3OPRK1OPRM1SMN1; SMN2MEN1 | |
| SCHEMBL7496624 | 0.80 | SLC6A3 (0.50) | SLC6A3OPRK1OPRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8556420 | 0.77 | MEN1 (0.41) | SLC6A3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4630703 | 0.72 | SLC6A3 (0.45) | SLC6A3MEN1KMT2ARAB9ASLC6A2 | |
| SCHEMBL8592295 | 0.72 | MEN1 (0.38) | SLC6A3OPRK1OPRM1P2RX3ALDH1A1 | |
| SCHEMBL6722595 | 0.72 | MEN1 (0.54) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |