Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300283 | 0.78 | MEN1 (0.40) | MEN1KMT2AKCNA5SCN5ASLC6A3 | |
| SCHEMBL8290867 | 0.77 | MEN1 (0.39) | MEN1KMT2AKCNA5SCN5ASLC6A3 | |
| SCHEMBL8593268 | 0.77 | SLC6A3 (0.38) | MEN1KMT2ASLC6A3SIGMAR1CYP1A2 | |
| SCHEMBL8316137 | 0.75 | SLC6A3 (0.45) | MEN1KMT2AKCNA5SCN5ASLC6A3 | |
| SCHEMBL7847786 | 0.74 | MEN1 (0.42) | MEN1KMT2AKCNA5SCN5ASLC6A3 | |
| SCHEMBL8590301 | 0.73 | SLC6A3 (0.37) | MEN1KMT2ASLC6A3SIGMAR1CYP1A2 | |
| SCHEMBL4631262 | 0.72 | SLC6A3 (0.43) | MEN1KMT2AKCNA5SCN5ASLC6A3 | |
| SCHEMBL6543753 | 0.70 | MEN1 (0.38) | MEN1KMT2ASLC6A3TSHRKDM4E | |
| SCHEMBL8484373 | 0.70 | MEN1 (0.38) | MEN1KMT2ASLC6A3TSHRKDM4E | |
| SCHEMBL8745696 | 0.69 | MEN1 (0.34) | MEN1KMT2ASLC6A3KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807865-A | 3,3-disubstituted piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |