Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601785 | 0.90 | TP53 (0.48) | PTGESTP53ALDH1A1CYP2C9APEX1 | |
| SCHEMBL8597238 | 0.88 | MMP2 (0.42) | PTGESTP53ALDH1A1LMNA | |
| SCHEMBL8597440 | 0.87 | KDM4E (0.40) | PTGESALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8596165 | 0.87 | TP53 (0.45) | PTGESTP53CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8599169 | 0.87 | PIK3CD (0.39) | PTGESALDH1A1KDM4E | |
| SCHEMBL8597312 | 0.86 | TP53 (0.43) | PTGESTP53CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8601161 | 0.85 | TP53 (0.46) | PTGESTP53ALDH1A1CYP2C9APEX1 | |
| SCHEMBL8597937 | 0.85 | TP53 (0.43) | PTGESTP53TYK2 | |
| SCHEMBL8597372 | 0.84 | PTGES (0.45) | PTGESTP53TYK2 | |
| SCHEMBL8596861 | 0.84 | TP53 (0.40) | PTGESTP53TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |