Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258128 | 0.87 | SIRT1 (0.63) | SIRT1SIRT2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11848642 | 0.83 | KDM4E (0.50) | SIRT1SIRT2KDM4EALDH1A1 | |
| Sulfuric Acid SCHEMBL8592514 | 0.82 | SIRT1 (0.57) | SIRT1SIRT2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11830018 | 0.82 | SIRT1 (0.53) | SIRT1SIRT2MAPKAPK2 | |
| SCHEMBL11835576 | 0.81 | GABRA1 (0.44) | SIRT1SIRT2CASP1MAPKAPK2SIGMAR1 | |
| SCHEMBL11830770 | 0.81 | SIRT1 (0.65) | SIRT1SIRT2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL901479 | 0.80 | TSPO (0.55) | SIRT1SIRT2SMN1; SMN2 | |
| SCHEMBL11844570 | 0.80 | SIRT2 (0.43) | SIRT1SIRT2KDM4EALDH1A1CASP1 | |
| SCHEMBL8574636 | 0.79 | SIRT2 (0.42) | SIRT1SIRT2KDM4EALDH1A1CASP1 | |
| SCHEMBL14473893 | 0.78 | BRD3 (0.58) | SIRT1SIRT2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022178-A1 | ENANTIOMERIC SEPARATION AND PURIFICATION OF 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-4-CARBOXYLIC ACID AMIDE DERIVATIVES | GE Healthcare Limited (GB) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015007834-A1 | ENANTIOMERIC SEPARATION AND PURIFICATION OF 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-4-CARBOXYLIC ACID AMIDE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2015-01-22 | — | — | WO | disclosed |
| WO-1998055115-A1 | CARBOXAMIDES USEFUL AS 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-12-10 | — | — | WO | disclosed |
| US-3948939-A | 9-Acyl-1,2,3,4-tetrahydrocarbazole-3 and 4-carboxylic acids | STERLING DRUG INC. (US) | 1976-04-06 | — | — | US | disclosed |