Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334839 | 0.74 | TSHR (0.46) | — | |
| SCHEMBL29617408 | 0.74 | TSHR (0.46) | — | |
| SCHEMBL28706328 | 0.74 | SLC6A2 (0.42) | PDE10ACYP1A2 | |
| SCHEMBL2353460 | 0.73 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL30233726 | 0.71 | CDK4 (0.47) | — | |
| SCHEMBL3576716 | 0.71 | CDK4 (0.47) | — | |
| SCHEMBL7720340 | 0.71 | GPBAR1 (0.46) | CYSLTR1CYSLTR2GPBAR1PDE10ACYP1A2 | |
| SCHEMBL28696512 | 0.71 | CDK4 (0.37) | — | |
| Cyclohexane SCHEMBL3204446 | 0.70 | TSHR (0.43) | — | |
| SCHEMBL5558132 | 0.70 | PDE10A (0.50) | CYSLTR1CYSLTR2GPBAR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691972-B1 | FURO 3,2-b]PYRIDINES AND THIENO 3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 1998-07-01 | — | — | EP | disclosed |
| EP-0535925-B1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC (CA) | 1996-04-24 | — | — | EP | disclosed |
| EP-0691972-A1 | FURO 3,2-b]PYRIDINES AND THIENO 3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-01-17 | — | — | EP | disclosed |
| EP-0544819-B1 | INDOLE DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5389650-A | Antiinflammatory agents, anticoagulants, antispasmodic agents | MERCK FROSST CANADA, INC. (CA) | 1995-02-14 | — | — | US | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| US-5374635-A | Antiinflammatory agents, lipoxygenase inhibitor, antiallergens , cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1994-12-20 | — | — | US | disclosed |
| WO-1994022869-A1 | FURO[3,2-b]PYRIDINES AND THIENO[3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-10-13 | — | — | WO | disclosed |
| US-5334719-A | Antihistamines, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1994-08-02 | — | — | US | disclosed |
| US-5252585-A | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-10-12 | — | — | US | disclosed |
| WO-1993016069-A1 | (AZAAROMATICALKOXY)INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1993-08-19 | — | — | WO | disclosed |
| EP-0542355-A1 | Amorphous (Quinolin-2-ylmethoxy)indoles as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1993-05-19 | — | — | EP | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| EP-0535923-A1 | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535924-A1 | (Bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535926-A1 | (Hetero-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535925-A1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| US-5190968-A | Antiinflammatory | MERCK FROSST CANADA, INC. (CA) | 1993-03-02 | — | — | US | disclosed |
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | disclosed |