Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | GNPAT | O15228 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcysteine SCHEMBL29226845 | 0.77 | MAPT (0.78) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL6835556 | 0.77 | KDM4E (0.70) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL3923962 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL5291 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL1384791 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL4437350 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL3688241 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL4437351 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL5292 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL149212 | 0.76 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699438-A2 | Use of neurotensin antagonists for the preparation of diuretic drugs | SANOFI (FR) | 1996-03-06 | — | — | EP | claimed |
| EP-0477049-A1 | Amido-3-pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-03-25 | — | — | EP | claimed |
| US-5955474-A | ANTIEDEMA AGENTS OR DIURETIC ANTAGONIST | SANOFI (FR) | 1999-09-21 | — | — | US | disclosed |
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5635526-A | POSSESSES ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM OR THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1997-06-03 | — | — | US | disclosed |
| US-5616592-A | USEFUL FOR DISORDERS OF CARDIOVASCULAR, GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | SANOFI (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5607958-A | NEUROTENSIN RECEPTOR BINDERS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |
| EP-0699438-A2 | Use of neurotensin antagonists for the preparation of diuretic drugs | SANOFI (FR) | 1996-03-06 | — | — | EP | disclosed |
| US-5420141-A | Capable of binding to neurotensin receptor | SANOFI (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0477049-A1 | Amido-3-pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-03-25 | — | — | EP | disclosed |