Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.66 |
| ▸ | HTR2A | P28223 | 17/20 | 0.63 |
| ▸ | HTR2B | P41595 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596900 | 1.00 | HTR2C (0.66) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8874855 | 0.89 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8873561 | 0.89 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8873554 | 0.89 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8874862 | 0.89 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| SCHEMBL7093740 | 0.81 | HTR2C (0.81) | HTR2CHTR2AHTR2B | |
| SCHEMBL7997598 | 0.81 | HTR2C (0.81) | HTR2CHTR2AHTR2B | |
| SCHEMBL8874209 | 0.80 | HTR2C (0.46) | HTR2CHTR2A | |
| SCHEMBL6365952 | 0.76 | HTR2C (0.70) | HTR2CHTR2AHTR2B | |
| SCHEMBL7767788 | 0.76 | HTR2C (0.70) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | claimed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | claimed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | claimed |
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |