Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 18/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 16/20 | 0.52 |
| ▸ | HTR2B known ✓ | P41595 | 6/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8874855 | 1.00 | HTR2C (0.54) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8874862 | 1.00 | HTR2C (0.54) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8873561 | 1.00 | HTR2C (0.54) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL8596238 | 0.89 | HTR2C (0.66) | HTR2CHTR2AHTR2B | |
| SCHEMBL8596900 | 0.89 | HTR2C (0.66) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL7088510 | 0.85 | HTR2C (0.64) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL7088508 | 0.85 | HTR2C (0.64) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8875730 | 0.84 | MTNR1A (0.42) | HTR2CHTR2AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8875723 | 0.84 | MTNR1A (0.42) | HTR2CHTR2AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL9001145 | 0.81 | HTR2C (0.58) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |