Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8875730 | 0.89 | MTNR1A (0.42) | HTR2CHTR2AMTNR1AMTNR1BDYRK1A | |
| Fumaric Acid SCHEMBL8875723 | 0.89 | MTNR1A (0.42) | HTR2CHTR2AMTNR1AMTNR1BDYRK1A | |
| SCHEMBL8596238 | 0.80 | HTR2C (0.66) | HTR2CHTR2A | |
| SCHEMBL8596900 | 0.80 | HTR2C (0.66) | HTR2CHTR2A | |
| SCHEMBL6803161 | 0.78 | HTR2C (0.63) | HTR2CHTR2AMAPTKDM4EMEN1 | |
| SCHEMBL8874163 | 0.78 | MTNR1A (0.72) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL19187660 | 0.75 | HTR2C (0.41) | HTR2CHTR2AMAPTKDM4EMEN1 | |
| Fumaric Acid SCHEMBL8874855 | 0.72 | HTR2C (0.54) | HTR2CHTR2AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8873554 | 0.72 | HTR2C (0.54) | HTR2CHTR2AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8873561 | 0.72 | HTR2C (0.54) | HTR2CHTR2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |