Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 5/20 | 0.39 |
| ▸ | CDK14 | O94921 | 4/20 | 0.38 |
| ▸ | CCNY | Q8ND76 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599264 | 0.84 | MEN1 (0.41) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8598365 | 0.83 | TYK2 (0.44) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8598941 | 0.82 | TYK2 (0.43) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8599534 | 0.80 | LMNA (0.41) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8597372 | 0.80 | PTGES (0.45) | TYK2PTGESMEN1KMT2APOLB | |
| SCHEMBL8595623 | 0.80 | TYK2 (0.41) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8597312 | 0.80 | TP53 (0.43) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8598065 | 0.79 | TYK2 (0.40) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8599983 | 0.79 | TYK2 (0.40) | TYK2PTGESMEN1KMT2ACRHBP | |
| SCHEMBL8596165 | 0.79 | TP53 (0.45) | TYK2PTGESMEN1KMT2ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |