Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10791261 | 0.85 | — | — | |
| SCHEMBL21719315 | 0.79 | ALOX5AP (0.31) | — | |
| SCHEMBL10966385 | 0.77 | RPS6KA5 (0.41) | ASPHULK1JUNNFKB1NFKB2 | |
| SCHEMBL8596569 | 0.77 | XPO1 (0.36) | JUNNFKB1NFKB2RELA | |
| SCHEMBL21719319 | 0.73 | — | — | |
| SCHEMBL9196036 | 0.73 | AURKA (0.33) | ULK1AURKAAXL | |
| SCHEMBL6633129 | 0.70 | KMT2A (0.39) | ASPH | |
| SCHEMBL9191163 | 0.70 | AURKA (0.32) | AURKA | |
| SCHEMBL1162292 | 0.69 | — | — | |
| SCHEMBL10681454 | 0.68 | CYP11B2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579020-B1 | Process for the preparation of 5-(Trifluoromethyl) uracil and as new compounds 2,4-dichloro-5-trichloromethyl pyrimidine and 2,4-dufluoro-5-trifluoromethyl-pyrimidine | BAYER AG (DE) | 1998-01-21 | — | — | EP | claimed |
| US-5352787-A | Process for the preparation of 5-(trifluoromethyl)-uracil, and the novel compounds 2,4-dichloro-5-trichloromethyl-pyrimidine and 2,4-difluoro-5-trifluoromethyl-pyrimidine | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-04 | — | — | US | claimed |
| EP-0579020-A1 | Process for the preparation of 5-(Trifluoromethyl) uracil and as new compounds 2,4-dichloro-5-trichloromethyl pyrimidine and 2,4-dufluoro-5-trifluoromethyl-pyrimidine | BAYER AG (DE) | 1994-01-19 | — | — | EP | claimed |
| JP-6073023-A | — | — | None | — | — | JP | disclosed |
| WO-2014076085-A1 | NOVEL PROCESS FOR THE MANUFACTURE OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-22 | — | — | WO | disclosed |
| US-20140135497-A1 | SYNTHESIS OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| US-20140135497-A1 | SYNTHESIS OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| EP-0579020-B1 | Process for the preparation of 5-(Trifluoromethyl) uracil and as new compounds 2,4-dichloro-5-trichloromethyl pyrimidine and 2,4-dufluoro-5-trifluoromethyl-pyrimidine | BAYER AG (DE) | 1998-01-21 | — | — | EP | disclosed |
| EP-0579020-B1 | Process for the preparation of 5-(Trifluoromethyl) uracil and as new compounds 2,4-dichloro-5-trichloromethyl pyrimidine and 2,4-dufluoro-5-trifluoromethyl-pyrimidine | BAYER AG (DE) | 1998-01-21 | — | — | EP | disclosed |
| US-5502173-A | Process for the preparation of a substituted 2-amino-1-sulphonaphthalene | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5352787-A | Process for the preparation of 5-(trifluoromethyl)-uracil, and the novel compounds 2,4-dichloro-5-trichloromethyl-pyrimidine and 2,4-difluoro-5-trifluoromethyl-pyrimidine | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-04 | — | — | US | disclosed |
| US-4118382-A | DYES FOR CELLULOSE, WOOL, SILK, POLYAMIDE, AND POLYURETHANE FIBERS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4089895-A | COUPLER FOR AZO DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-16 | — | — | US | disclosed |
| US-4065446-A | Reactive dyestuffs containing urea alkylene linkage between chromophore and reactive radical | BAYER AKTIENGESELLSCHAFT (DT) | 1977-12-27 | — | — | US | disclosed |
| US-4052386-A | REACTIVE PHTHALOCYANINE DYESTUFFS CONTAINING A FLUOROPYRIMIDINYL GROUP | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-04 | — | — | US | disclosed |
| US-4049704-A | AZO REACTIVE DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | disclosed |
| US-4024123-A | TEXTILES | DUSSY PAUL | 1977-05-17 | — | — | US | disclosed |
| US-3989692-A | PHTHALOCYANINE DYES, WOOL, SILK, POLYAMIDES, CELLULOSE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-02 | — | — | US | disclosed |
| US-3988310-A | FIBER-REACTIVE DYES; CELLULOSE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-26 | — | — | US | disclosed |
| US-3957751-A | WATER-SOLUBLE REACTIVE DYESTUFFS OF THE MONOAZO SERIES CONTAINING AN ACTIVE METHYLENE COUPLING COMPONENT | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135497-A1 | SYNTHESIS OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE | DPYD, DHFR, DHPS | ASPH 2951/4885ULK1 3006/4885JUN 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.