SCHEMBL859909

SCHEMBL859909

CC(C)CC(=O)ON1C(=O)c2ccc(Oc3ccc4c(c3)C(=O)N(OC(=O)CC(C)C)C4=O)cc2C1=O

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.50
POLB P06746 3/20 0.49
LPAR3 Q9UBY5 2/20 0.48
LPAR1 Q92633 1/20 0.48
ALDH1A1 P00352 4/20 0.46
KMT2A Q03164 3/20 0.46
KDM4E B2RXH2 3/20 0.46
MEN1 O00255 2/20 0.46
HTT P42858 1/20 0.46
HSD17B10 Q99714 2/20 0.45
MAPK1 P28482 1/20 0.45
BRD4 O60885 1/20 0.40
NPSR1 Q6W5P4 2/20 0.40
MAPT P10636 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL860107 0.83 ALDH1A1 (0.46) TDP1POLBALDH1A1KMT2AKDM4E
SCHEMBL31463689 0.82 ALDH1A1 (0.47) ALDH1A1KMT2AMEN1MAPTCYP2C9
SCHEMBL859768 0.82 TDP1 (0.51) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL859504 0.81 ALDH1A1 (0.47) POLBALDH1A1KDM4EHTTHSD17B10
SCHEMBL859692 0.79 POLB (0.60) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL860083 0.78 TNF (0.39) ALDH1A1KMT2AKDM4EHSD17B10NPSR1
SCHEMBL12541822 0.72 POLB (0.54) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL860087 0.71 TDP1 (0.52) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL24461857 0.71 ALDH1A1 (0.44) ALDH1A1KMT2AMEN1MAPTCYP2C9
SCHEMBL12540869 0.71 POLB (0.53) TDP1POLBLPAR3LPAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2100731-B1 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORP (JP) 2012-06-20 EP disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed