SCHEMBL860107

SCHEMBL860107

CC(C)CC(=O)ON1C(=O)c2ccc(C(=O)c3ccc4c(c3)C(=O)N(OC(=O)CC(C)C)C4=O)cc2C1=O

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.46
TSHR P16473 1/20 0.46
ENPP2 Q13822 1/20 0.44
APEX1 P27695 1/20 0.43
POLB P06746 2/20 0.41
LMNA P02545 2/20 0.40
MEN1 O00255 6/20 0.39
KMT2A Q03164 6/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
MAPK1 P28482 1/20 0.39
NPC1 O15118 3/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
RAB9A P51151 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL859909 0.83 TDP1 (0.50) ALDH1A1POLBMEN1KMT2AKDM4E
SCHEMBL31463689 0.82 ALDH1A1 (0.47) ALDH1A1TSHRLMNAMEN1KMT2A
SCHEMBL859500 0.82 ALDH1A1 (0.47) ALDH1A1TSHRENPP2APEX1POLB
SCHEMBL859504 0.81 ALDH1A1 (0.47) ALDH1A1TSHRPOLBKDM4EMAPT
SCHEMBL860092 0.79 ALDH1A1 (0.49) ALDH1A1TSHRENPP2APEX1POLB
SCHEMBL860083 0.78 TNF (0.39) ALDH1A1KMT2AKDM4EMAPTNPSR1
SCHEMBL13622430 0.77 ALDH1A1 (0.46) ALDH1A1TSHRENPP2APEX1POLB
SCHEMBL859698 0.72 APEX1 (0.52) ALDH1A1TSHRENPP2APEX1POLB
SCHEMBL860111 0.72 LMNA (0.51) ALDH1A1TSHRENPP2APEX1POLB
SCHEMBL15762473 0.72 ALDH1A1 (0.51) ALDH1A1TSHRENPP2APEX1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed