SCHEMBL8599400

SCHEMBL8599400

CC(N)CC1(CC(=O)O)C=Nc2ccccc21

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.32
AKR1B1 P15121 1/20 0.31
SLC6A2 P23975 2/20 0.30
TAAR1 Q96RJ0 2/20 0.30
MAOA P21397 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30
SIGMAR1 Q99720 1/20 0.30
CYP2A6 P11509 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29051906 0.77 APEX1 (0.35) AKR1B1
SCHEMBL2490028 0.70 AKR1B1 (0.39) AKR1B1
SCHEMBL29089254 0.69 ALPI (0.39) KIF11
SCHEMBL14840086 0.69 ALPI (0.39) KIF11
SCHEMBL5668472 0.69 ALDH1A1 (0.38) AKR1B1
SCHEMBL28472018 0.69 HTT (0.34) AKR1B1
SCHEMBL30625890 0.68 SLC7A5 (0.41) KIF11
Hydrochloric Acid SCHEMBL27357806 0.67 TSHR (0.35)
SCHEMBL20362157 0.67 APEX1 (0.33) AKR1B1
SCHEMBL24495475 0.66 TDP1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0817621-A1 PHARMACEUTICAL COMPOSITION FOR TRANSDERMIC DELIVERY SANOFI (FR) 1998-01-14 EP disclosed
WO-1996030000-A1 PHARMACEUTICAL COMPOSITION FOR TRANSDERMIC DELIVERY SANOFI (FR) 1996-10-03 WO disclosed