Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25950783 | 0.81 | TSHR (0.43) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL2125979 | 0.80 | ALDH1A1 (0.65) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL14994077 | 0.79 | SMN1; SMN2 (0.59) | TSHRALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL7965902 | 0.78 | ALDH1A1 (0.59) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL11230620 | 0.78 | TSHR (0.52) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL10256214 | 0.78 | NR1H4 (0.49) | TSHRALDH1A1HSD17B10MAPK1HIF1A | |
| SCHEMBL7447640 | 0.77 | ABL1 (0.56) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL6744997 | 0.77 | TSHR (0.51) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL5570026 | 0.76 | ERCC5 (0.57) | TSHRALDH1A1TDP1RECQLALOX15 | |
| SCHEMBL28318361 | 0.76 | KDM4E (0.50) | TSHRALDH1A1HPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005961-A1 | COMPOUNDS HAVING A PLURALITY OF NITROGENOUS SUBSTITUENTS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-12 | — | — | WO | disclosed |