Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29592557 | 0.76 | LMNA (0.58) | KDM4EAXLNUDT1PSMD14LMNA | |
| SCHEMBL1159986 | 0.76 | LMNA (0.58) | KDM4EAXLNUDT1PSMD14LMNA | |
| SCHEMBL2487781 | 0.76 | ADRA2A (0.42) | KDM4EAXLNUDT1PSMD14LMNA | |
| SCHEMBL30954657 | 0.76 | ADRA2A (0.42) | KDM4EAXLNUDT1PSMD14LMNA | |
| SCHEMBL324668 | 0.75 | KDM4E (0.47) | KDM4ELMNAMMP2TSHRGMNN | |
| SCHEMBL455351 | 0.74 | KDM4E (0.53) | KDM4EALOX15SMN1; SMN2AHRGPR3 | |
| SCHEMBL8600442 | 0.73 | AXL (0.46) | KDM4EAXLNUDT1PSMD14LMNA | |
| SCHEMBL27673186 | 0.73 | KDM4E (0.52) | KDM4EALOX15SMN1; SMN2AHRGPR3 | |
| Iodide SCHEMBL4717590 | 0.73 | KDM4E (0.52) | KDM4EALOX15SMN1; SMN2AHRGPR3 | |
| Hydrochloric Acid SCHEMBL3881151 | 0.73 | KDM4E (0.52) | KDM4EALOX15SMN1; SMN2AHRGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587473-B1 | Condensed pyridine derivatives as inhibitors of the effects of free radicals | SANOFI SA (FR) | 1998-11-11 | — | — | EP | disclosed |
| US-5468750-A | Antiinflammatory agents and autoimmune diseases | ELF SANOFI (FR) | 1995-11-21 | — | — | US | disclosed |
| US-5360799-A | Free radical inhibitors | ELF SANOFI (FR) | 1994-11-01 | — | — | US | disclosed |
| EP-0587473-A1 | Condensed pyridine derivatives as inhibitors of the effects of free radicals | SANOFI (FR) | 1994-03-16 | — | — | EP | disclosed |