SCHEMBL8600743

SCHEMBL8600743

O=C(O)COc1cccc2c1CCC(CNS(=O)(=O)C=Cc1ccccc1)C2

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 20/20 0.55
PTGDR Q13258 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8600745 0.87 PTGIR (0.40) PTGIR
SCHEMBL8602826 0.85 PTGIR (0.50) PTGIR
SCHEMBL8602824 0.85 PTGIR (0.50) PTGIR
SCHEMBL8858465 0.78 PTGIR (0.64) PTGIRPTGDR
SCHEMBL8627438 0.77 PTGIR (0.50) PTGIRPTGDR
SCHEMBL8414260 0.76 PTGIR (0.65) PTGIRPTGDR
SCHEMBL8858428 0.75 PTGIR (0.64) PTGIRPTGDR
SCHEMBL8626228 0.74 PTGIR (0.57) PTGIR
SCHEMBL8626475 0.74 PTGIR (0.57) PTGIR
SCHEMBL7778598 0.74 PTGIR (0.69) PTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657422-B1 Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists ONO PHARMACEUTICAL CO (JP) 1998-06-10 EP claimed
EP-0657422-A1 Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 1995-06-14 EP claimed
EP-0657422-B1 Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists ONO PHARMACEUTICAL CO (JP) 1998-06-10 EP disclosed
US-5723493-A PROSTAGLANDIN DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 1998-03-03 US disclosed
US-5624959-A INHIBITING UTERINE CONTRACTIONS, PROSTAGLANDIN ANTAGONIST OR AGONIST, ANALGESICS AND ANTISECRETORY AGENTS ONO PHARMACEUTICAL CO., LTD. (JP) 1997-04-29 US disclosed
EP-0657422-A1 Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 1995-06-14 EP disclosed