Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 7/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874447 | 1.00 | METAP1 (0.47) | METAP1ACHEPBRM1TDP1L3MBTL1 | |
| SCHEMBL8600861 | 1.00 | METAP1 (0.47) | METAP1ACHEPBRM1TDP1L3MBTL1 | |
| SCHEMBL7889589 | 0.86 | METAP1 (0.45) | METAP1ACHEPBRM1TDP1L3MBTL1 | |
| SCHEMBL8596188 | 0.86 | CYP19A1 (0.43) | METAP1ACHEPBRM1 | |
| SCHEMBL8596190 | 0.86 | CYP19A1 (0.43) | METAP1ACHEPBRM1 | |
| SCHEMBL8874593 | 0.86 | CYP19A1 (0.43) | METAP1ACHEPBRM1 | |
| SCHEMBL8873299 | 0.84 | METAP1 (0.59) | METAP1ACHEPARP1PARP10 | |
| SCHEMBL8595392 | 0.84 | METAP1 (0.59) | METAP1ACHEPARP1PARP10 | |
| SCHEMBL8595390 | 0.84 | METAP1 (0.59) | METAP1ACHEPARP1PARP10 | |
| SCHEMBL8600959 | 0.84 | METAP1 (0.50) | METAP1ACHEPBRM1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |