Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608604 | 0.92 | KDM4E (0.67) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9720944 | 0.89 | KDM4E (0.64) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL783686 | 0.89 | KDM4E (0.64) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9721024 | 0.89 | KDM4E (0.64) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL8601357 | 0.89 | KDM4E (1.00) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9642123 | 0.88 | MAPT (0.78) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL6753972 | 0.88 | GAA (0.64) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL7033532 | 0.87 | MAPT (0.72) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL7867650 | 0.86 | PKM (0.67) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL522319 | 0.82 | MAPT (0.57) | KDM4EMAPTALDH1A1KCNJ1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763473-A | Use of 2-substituted benzimidazole as smooth muscle cell proliferation inhibitors | AMERICAN HOME PROCUCTS CORPORATION (US) | 1998-06-09 | — | — | US | disclosed |
| US-5654436-A | INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |