SCHEMBL8601531

SCHEMBL8601531

COC(=O)Cc1sc(F)c(N=C=S)c1Cl

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.31
HSD17B10 Q99714 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9035934 0.88 HTT (0.31) HTTHSD17B10
SCHEMBL8604179 0.87 TRPM8 (0.33) GABRA1GABRB2
SCHEMBL8602852 0.83 GABRA1 (0.30) GABRA1GABRB2
SCHEMBL8601299 0.82
SCHEMBL8602427 0.80 CYP19A1 (0.35)
SCHEMBL7689951 0.80 HTT (0.31) HTTHSD17B10
SCHEMBL8603882 0.79
SCHEMBL8598910 0.76 GABRA1 (0.41) GABRA1GABRB2
SCHEMBL8603113 0.76 KMT2A (0.39) HSD17B10
SCHEMBL8602580 0.74 GABRA1 (0.35) GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
EP-0523244-B1 SALT OF DITHIOCARBAMIC ACID, PRODUCTION THEREOF, AND PRODUCTION OF ISOTHIOCYANATE FROM SAID SALT IHARA CHEMICAL IND CO (JP) 1996-04-10 EP disclosed
US-5416065-A Herbicidal thiadiazabicyclooctanes CIBA-GEIGY CORPORATION (US) 1995-05-16 US disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed
US-5274166-A Dithiocarbamic acid salt, process for production thereof, and process for production of isothiocyanate using said dithiocarbamic acid salt IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1993-12-28 US disclosed
EP-0523244-A1 SALT OF DITHIOCARBAMIC ACID, PRODUCTION THEREOF, AND PRODUCTION OF ISOTHIOCYANATE FROM SAID SALT IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1993-01-20 EP disclosed