SCHEMBL8602009

SCHEMBL8602009

O=C(Nc1cccc2[nH]c(CC(F)(F)F)nc12)c1c(Cl)cccc1Cl

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGES O14684 17/20 0.48
TRPV1 Q8NER1 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8597761 0.85 PTGES (0.52) PTGESTRPV1
SCHEMBL8599475 0.82 TRPV1 (0.65) PTGESTRPV1
SCHEMBL8569632 0.78 TRPV1 (0.58) PTGESTRPV1
SCHEMBL8600699 0.78 TRPV1 (0.43) PTGESTRPV1
SCHEMBL8597015 0.76 MAOB (0.43) PTGESTRPV1
SCHEMBL8597518 0.75 PTGES (0.51) PTGESTRPV1
SCHEMBL8662196 0.74 PTGES (0.52) PTGESTRPV1
SCHEMBL8597130 0.71 MEN1 (0.38) PTGES
SCHEMBL8560232 0.70 TYK2 (0.52) PTGES
SCHEMBL8473813 0.68 RAB9A (0.47) PTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863881-A1 BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-16 EP disclosed
WO-1997010219-A1 BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-20 WO disclosed