Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128419 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL5319001 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPTMAPK1L3MBTL1SLC6A2 | |
| SCHEMBL4167580 | 0.74 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL5230410 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL9785319 | 0.71 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL20052615 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MAPTHPGDMAPK1L3MBTL1 | |
| SCHEMBL7416001 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MAPTMAPK1L3MBTL1SLC6A2 | |
| SCHEMBL7424759 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL11233359 | 0.70 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL4160510 | 0.70 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |