Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9391305 | 0.87 | ALDH1A1 (0.45) | ALDH1A1HTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8216557 | 0.85 | ALDH1A1 (0.42) | ALDH1A1HTR2CSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL9653966 | 0.80 | NPC1 (0.43) | ALDH1A1HTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6870816 | 0.76 | MEN1 (0.49) | KMT2AMAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL4160510 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| E1501 SCHEMBL27564104 | 0.72 | ALDH1A1 (0.79) | ALDH1A1HTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11256962 | 0.71 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMAPK1L3MBTL1 | |
| SCHEMBL5230410 | 0.70 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL8602160 | 0.70 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL9785319 | 0.70 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341781-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-07-27 | — | — | US | disclosed |