Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 10/20 | 0.61 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476359 | 0.91 | CHEK2 (0.50) | CHEK2NPBWR1HSP90AA1ESR2TDP1 | |
| SCHEMBL5217725 | 0.81 | CHEK2 (0.87) | CHEK2NPBWR1NR4A2MAPTRAB9A | |
| SCHEMBL8604389 | 0.81 | CHEK2 (0.57) | CHEK2NPBWR1HSP90AA1ESR2TDP1 | |
| SCHEMBL8602741 | 0.81 | CHEK2 (0.57) | CHEK2NPBWR1HSP90AA1ESR2TDP1 | |
| SCHEMBL8299626 | 0.80 | CHEK2 (0.51) | CHEK2NPBWR1F2F10PLG | |
| SCHEMBL8600314 | 0.78 | CHEK2 (0.60) | CHEK2NPBWR1HSP90AA1ESR2TDP1 | |
| SCHEMBL5221558 | 0.77 | NPBWR1 (0.80) | CHEK2NPBWR1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6643380 | 0.76 | CHEK2 (1.00) | CHEK2NPBWR1NR4A2MAPTRAB9A | |
| SCHEMBL8601049 | 0.76 | CHEK2 (0.58) | CHEK2NPBWR1HSP90AA1ESR2TDP1 | |
| SCHEMBL3167456 | 0.76 | CHEK2 (0.57) | CHEK2NPBWR1HSP90AA1ESR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |