SCHEMBL8604387

SCHEMBL8604387

C=CCOc1ccc(-c2cc(-c3ccccn3)ccc2C=CCCCC(C)F)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SQOR Q9Y6N5 1/20 0.40
DCTPP1 Q9H773 1/20 0.40
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP19A1 P11511 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
METAP1 P53582 1/20 0.36
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
OPRD1 P41143 1/20 0.31
PIK3CD O00329 1/20 0.31
PIK3CA P42336 1/20 0.31
PI4KA P42356 1/20 0.31
PIK3CG P48736 1/20 0.31
PI4KB Q9UBF8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8602518 0.90 SQOR (0.32) SQORDCTPP1CYP2D6CHRNB2CHRNB4
SCHEMBL8601045 0.88 CYP2D6 (0.39) SQORDCTPP1CYP2D6CYP19A1CYP2C9
SCHEMBL8602701 0.87 SQOR (0.34) SQORCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL8601977 0.87 SQOR (0.39) SQORDCTPP1CYP1A2CYP2D6CYP19A1
SCHEMBL8596620 0.81 DCTPP1 (0.41) SQORDCTPP1CYP1A2CYP2D6CYP19A1
SCHEMBL8600713 0.81 PIK3CD (0.34) SQORCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL8601987 0.79 SQOR (0.40) SQORDCTPP1CYP1A2CYP2D6CYP19A1
SCHEMBL8599482 0.76 SQOR (0.38) SQORDCTPP1MEN1KMT2AGAA
SCHEMBL8600215 0.76 ALOX5 (0.30)
SCHEMBL8603472 0.76 DCTPP1 (0.33) SQORDCTPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5779934-A FLUORINATING AN ALCOHOL DERIVATIVE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-07-14 US disclosed