Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27671940 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL9474617 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL8760886 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL8760880 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL11044892 | 0.87 | HCAR2 (0.54) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL10493320 | 0.87 | HSD17B10 (0.70) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Hydrogen Peroxide SCHEMBL15610564 | 0.86 | — | — | |
| Hydrogen Peroxide SCHEMBL28219767 | 0.86 | TSHR (0.91) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL28864083 | 0.86 | — | — | |
| Fumaric Acid SCHEMBL27663516 | 0.84 | HCAR2 (0.65) | ALDH1A1TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343981-B2 | Use of an additive in a fuel oil composition as a flow improver | EXXON CHEMICAL PATENTS INC (US) | 1998-02-25 | — | — | EP | disclosed |