Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586638 | 0.81 | TNKS2 (0.64) | ALDH1A1KMT2AMEN1HPGDHTT | |
| SCHEMBL10144731 | 0.77 | KMT2A (0.66) | KMT2AMEN1KDM4ERAB9AMAPT | |
| SCHEMBL463268 | 0.76 | DDAH1 (0.59) | ALDH1A1KMT2AMEN1HPGDRAB9A | |
| Hydrogen Sulfide SCHEMBL29094907 | 0.75 | DDAH1 (0.58) | ALDH1A1KMT2AMEN1HPGDRAB9A | |
| Iodide SCHEMBL29040436 | 0.75 | DDAH1 (0.58) | ALDH1A1KMT2AMEN1HPGDRAB9A | |
| SCHEMBL28633738 | 0.75 | DDAH1 (0.58) | ALDH1A1KMT2AMEN1HPGDRAB9A | |
| Biphenyl SCHEMBL28917228 | 0.74 | GAA (0.54) | ALDH1A1KMT2AMEN1HPGDRAB9A | |
| SCHEMBL29212566 | 0.72 | PDE10A (0.40) | ALDH1A1KMT2AMEN1HPGDHTT | |
| SCHEMBL9228130 | 0.71 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1HPGDHTT | |
| Carbamic Acid SCHEMBL7194349 | 0.71 | CHRM1 (0.56) | ALDH1A1HTTKDM4ERAB9APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143252-B2 | Tetrahalogenated compounds useful as inhibitors of angiogenesis | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-03-27 | — | — | US | disclosed |