Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795283 | 0.81 | RAD51 (0.42) | MCHR1HDAC6CCNA2CDK2CCNA1 | |
| SCHEMBL16874867 | 0.79 | CCR1 (0.42) | MCHR1CCNA2CDK2CCNA1 | |
| SCHEMBL5846834 | 0.78 | ROCK2 (0.50) | HDAC6FPR2CCNA2CDK2CCNA1 | |
| SCHEMBL18048847 | 0.78 | ROCK2 (0.50) | HDAC6FPR2CCNA2CDK2CCNA1 | |
| SCHEMBL16422794 | 0.78 | FPR2 (0.48) | FPR2CCNA2CDK2CCNA1ROCK2 | |
| SCHEMBL18048717 | 0.78 | ROCK2 (0.50) | HDAC6FPR2CCNA2CDK2CCNA1 | |
| SCHEMBL8606291 | 0.78 | MCHR1 (0.46) | MCHR1ROCK2 | |
| SCHEMBL15325269 | 0.77 | MCHR1 (0.37) | MCHR1HDAC6FPR2CCNA2CDK2 | |
| SCHEMBL8089006 | 0.77 | TSHR (0.36) | MCHR1TSHRL3MBTL1IDO1 | |
| SCHEMBL8604544 | 0.76 | HDAC6 (0.42) | MCHR1HDAC6FPR2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828710-A1 | PROCESS FOR THE PREPARATION OF (THIO-)CARBONIC/CARBAMIC ACID 2-PYRROLIDONYL-3-ESTERS, THIO ESTERS AND AMIDES | ZENECA LIMITED (GB) | 1998-03-18 | — | — | EP | disclosed |
| US-5670656-A | Process for preparing pyrrolidinones | ZENECA LIMITED (GB) | 1997-09-23 | — | — | US | disclosed |
| WO-1996037466-A1 | PROCESS FOR THE PREPARATION OF (THIO-)CARBONIC/CARBAMIC ACID 2-PYRROLIDONYL-3-ESTERS, THIO ESTERS AND AMIDES | ZENECA LIMITED (GB) | 1996-11-28 | — | — | WO | disclosed |